Paola Andrea Ortiz MarÃn, Andrés Felipe Segura Ãvila, Juan Camilo Arcia Garzón, Diana Marcela RodrÃguez Andrade, José Daniel Sierra Reyes, Rosana MarÃa Babilonia Yepes, Daniel Forero Henao, Edwin Alejandro Barón Muñoz, William Mauricio Prieto Beltrán and Juan David Vega Padilla
Objective: To conduct a review of the literature about sepsis and septic shock in adults.
Methodology: An extensive literature search using multiple databases (Medline, Embase, Scopus, and Science Direct) was used to identify articles from 2013 to 2019 that evaluated the sepsis and septic shock. The keywords “sepsis” and “septic shock” were used. Approximately 1,200 abstracts were identified initially and of these, 35 artic les were selected.
Results: Sepsis is a major cause of death, disability, and cost to the health care system. The new definition of sepsis is “life-threatening organ dysfunction caused by a dysregulated host response to infection” the current management of sepsis primarily involves early resuscitation (Administer intravenous fluid, mean arterial pressure ≥ 65 mmHg, normalize lactate, use vasopressors), and infection control (The current guidelines recommend initiation of intravenous antimicrobials within 1 hour of recognition of sepsis and septi c shock).
Conclusion: Sepsis and septic shock should be diagnosed and treated effectively to reduce morbidity and mortality in intensive care units and emergency departments.