Min Chen, Zhikang Zhao and Hongbo Liu
We reported a 52 years old female patient presented with sleep habit changing, slugishness and progressive legs weakness. Her brain MRI shows lesions in bilateral subcortex, bilateral periventricular region, left pedunculus cerebri, callosum, left thalamus, bilateral basal ganglia region, displaying longT1, long T2 signal, with some lesions enhanced after contrast administration. The pathology obtained from brain biopsy suggested diffuse large B-cell lymphoma.