Mohammed El-Said
Cellular therapy may be the solution of challenging
problems in colorectalsurgery such as impaired healing
leading to anastomotic leakage and metastaticcolorectal
cancer (CRC). This review aimed to illustrate the role
of cellulartherapy in promotion of wound healing and
management of metastatic CRC. Anorganized literature
search for the role of cellular therapy in promotion of
woundhealing and management of metastatic CRC was
conducted. Electronic databasesincluding PubMed/
Medline, Scopus, and Embase were queried for the
searchprocess. Two types of cellular therapy have been
recognized, the mesenchymalstem cells (MSCs) and bone
marrow-mononuclear cells (BM-MNCs) therapy.These
cells have been shown to accelerate and promote healing
of various tissueinjuries in animal and human studies. In
addition, experimental studies havereported that MSCs
may help suppress the progression of colon cancer in
ratmodels. This article reviews the possible mechanisms
of action and clinical utilityof MSCs and BM-MNCs in
promotion of healing and suppression of tumorgrowth
in light of the published literature. Cellular therapy has
a potentiallyimportant role in colorectal surgery, particularly
in the promotion of woundhealing and management
of metastatic CRC. Future directions of cellular
therapyin colorectal surgery were explored which may
help stimulate futures studies onthe role of cellular therapy
in colorectal surgery