Mengzhen Zhou, JiYouTang
Background: It is believed that the main pathological changes in Alzheimer's disease are abnormal deposition of β-amyloid (Aβ) protein and phosphorylation of tau in the brain, and various in vitro and in vivo experiments have shown that aquaporin 4 (AQP 4) may be responsible for Aβ metabolism and clearance in Alzheimer's disease.
Objective: To provide a new direction for the diagnosis and treatment of Alzheimer's disease by characterizing the structure and function of AQP 4 and the function and possible mechanism of AQP 4 in the clearance of Aβ in Alzheimer's disease.
Conclusion: Strengthening of the regulatory effect of Aqp 4 on lymphatic function in the brain has an important effect on the development, progression and outcome of Alzheimer's disease. Aqp 4 agonists or agents that induce AQP 4 opening are expected to become novel treatments for Alzheimer's disease.