Periodontal disease is the most common oral disease in carnivores with multifactorial etiology. According to modern opinion, periodontitis is caused by the interaction between bacterial microflora of the periodontal pocket and host defense mechanisms. There are also environmental factors that influence the tendency of periodontal disease. Since the 1970s, inflammatory response to plaque bacteria has been studied. As a result of the pathogenic effect of the bacteria on the periodontal tissues, a specific immune response occurs, which involves the activation of the body's defense processes and the generation of cytotoxic mechanisms, destructively affecting the tissues of the periodontium. Periodontal infections are usually mixed, most often involving anaerobes such as Treponema denticola and Porphyromonas gingivalis. The microaerophile Actinobacillus actinomycetemcomitans causes a rare form known as localized juvenile periodontitis. Periodontitis (per-e-o-don-TIE-tis), also called gum disease, is a serious gum infection that damages the soft tissue and, without treatment, can destroy the bone that supports your teeth. Periodontitis can cause teeth to loosen or lead to tooth loss.