Manish Tripathi
The exact incidence of AERD is not known. The clinical experience is limited to isolated case reports and clinicopathologic case discussions. There have been no prospective studies that focused on this problem in a systematic manner. Panum first described this entity in 1862. In a biopsy study, Jones and Lannaccone reported an incidence of 1.1%. AERD was diagnosed as the primary cause of renal failure in 1.9% of patients accepted for chronic dialysis. The reported incidence of AERD varied in the literature because of the differences in study design. However, during the past few years, the observed incidence of AERD in clinical practice seems to have increased. The possible reasons include increased clinical awareness, increased longevity of patients with atherosclerotic vascular disease, improved invasive vascular procedures, routine use of thrombolytics and anticoagulants in clinical practice, and different criteria used for making the diagnosis.